منابع مشابه
More efficient photolithographic synthesis of DNA-chips by photosensitization.
Light-induced release of photolabile protecting groups is a key step in the photolithographic in-situ synthesis of oligonucleotides in the production of high-density DNA-chips. Protecting groups of the o-nitrophenyl type that are preferentially used for this purpose have rather low absorption coefficients at 366 nm, the wavelength of the most conveniently used mercury line. The weak absorptivit...
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Several cationic porphyrins are known to bind to DNA by intercalative and outside binding modes. This study identifies the cis and trans isomers of bis(N-methyl-4-phridiniumyl)diphenyl porphyrin as DNA intercalators based on evidence from a DNA topoisomerase I assay. Moreover, both isomers are shown to be potent photosensitizers of DNA, inducing multiple S1 nuclease sensitive breaks in the phos...
متن کاملHydrogen abstraction by photoexcited benzophenone: consequences for DNA photosensitization.
We report a computational investigation of the hydrogen abstraction (H-abstraction) induced by triplet benzophenone ((3)BP) on thymine nucleobase and backbone sugar. The chemical process is studied using both high level multiconfigurational perturbation and density functional theory. Both methods show good agreement in predicting small kinetic barriers. Furthermore the behavior of benzophenone ...
متن کاملPhotosensitization by drugs*
Certain drugs are known to elicit photosensitivity side effects. A satisfactory understanding of the involved mechanistic aspects is necessary to anticipate the photosensitizing potential. We have used tiaprofenic acid (TPA), a photosensitizing nonsteroidal antiinflammatory drug, to illustrate the methodology followed to address this problem. After studying the photophysical and photochemical p...
متن کاملDetection of Quadruplex DNA by Gold Nanoparticles
Gold nanoparticles have been used as a probe to detect low (<10 ppb) concentrations of quadruplex DNA. These nanoparticles display a tendency to form aggregates in the presence of certain quadruplex forms, as observed via enhanced plasmon resonance light scattering (PRLS) signals. These nanoparticles showed differing degrees of interactions with different types of quadruplex and mixed sequences...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1978
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/5.10.3731